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If the solution becomes unexpectedly cloudy, develops discoloration, or contains foreign particulate matter that does not dissolve, the material should not be used for laboratory experiments until the cause has been determined

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On average, volunteers in the retatrutide clinical trial who received the study drug rather than a placebo lost an average of 70.3 pounds over about a year-and-a-half, with more than 45% of participants losing more than 30% of their body weight